DNA Methylation: A Key Player in Ovarian Serous Adenocarcinoma: A Review

Authors

  • Imrana Tanvir
  • Amer Shafie
  • Abdel Rahman

DOI:

https://doi.org/10.53350/pjmhs020241861

Abstract

Ovarian cancer, particularly serous adenocarcinoma, in women, is the most significant cause of cancer-related death, with its progression strongly linked to epigenetic modifications, notably DNA methylation. Epigenetic biomarkers, especially changes in DNA methylation patterns, have significant prognostic value in cancer, aiding in risk assessment and the development of therapeutic strategies. Two major epigenetic alterations are commonly seen: global DNA hypomethylation, which can activate oncogenes, and CpG island hypermethylation, which silences tumour suppressor genes. Understanding these epigenetic mechanisms not only deepens knowledge of ovarian cancer's molecular basis but also opens avenues for more accurate early detection, personalized treatment, and preventive measures.
Keywords: DNA methylation, Serous adenocarcinoma, Ovarian cancer, Epigenetic, hypermethylation

Downloads

How to Cite

Imrana Tanvir, Amer Shafie, & Abdel Rahman. (2024). DNA Methylation: A Key Player in Ovarian Serous Adenocarcinoma: A Review. Pakistan Journal of Medical & Health Sciences, 18(6), 3. https://doi.org/10.53350/pjmhs020241861

Issue

Vol. 18 No. 6 (2024): Pakistan Journal of Medical & Health Sciences

Section

Review Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.