Effects of Levetiracetam Drug an Magnesium on Hematological Parameter and some Biochemical Parameters in White Rats
DOI:
https://doi.org/10.53350/pjmhs22164888Keywords:
Levetiracetam ,magnesium, kidney, Rats.Abstract
Objective :The current study aimed to study the role of magnesium in reducing the effect of the Levetiracetam at a dose (25 mg/kg body weight) on hematological parameter and renal functions in White Rats.
Materials and Methods: Thirty two adult male rats of160 -170 grams weight were adopted. Rats randomly allocated in to four groups ;control ,Levetiracetam 25 mg ,Levetiracetam25 mg with magnesium(Mg+2)100mg and the four group Levetiracetam25 mg with magnesium(Mg+2)150mg .all groups were dosed daily for one month .
Results: the results revealed that levetiracetam causes significant decrease in hematological parameter(RBC, Hb , pcv)and significant elevations in WBC count ,and its causes significant elevations in renal urea and creatine comparing among the treatment groups with the control at (p≤0.05) .
The magnesium show demonstrated beneficial effects on hematological parameters renal functions in the present study.
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