Introduction: Recent studies have showed that student learn more significantly by the blend of words with pictorial outlines related to the topic than the words alone. So this avowal can be known as the interactive multimedia postulate, and it shapes the foundation for using sight and sound learning. Microsoft made PowerPoint in 1990. It is a PC program used for showing specific progressed content to target academic/social occasions of individuals. In mid-2009 new freeware programming was determined and named "Prezi", which maybe supplant the piece of PowerPoint.

Objective: The aim of this study is to evaluate the two presentation software in regards to their effectiveness by measuring through the series of assessments after the teaching session in Knowledge acquisition and knowledge retention test.

Material & Method

Methodology: This was a Quantitative Experimental study which was conducted in the Fatima Memorial college of Medicine and Dentistry Lahore. The participants were 66 of final year BDS students who voluntarily participated in the research project.

Results: A total of 66 students participated in the study and it was found a significant difference between the two intervention groups regarding the mean scores of Knowledge acquisition and knowledge retention test. The PowerPoint group showed lower grades in Knowledge acquisition and knowledge retention test in comparison with Prezi group. The learning performances was evaluated from immediate learning responses in Knowledge acquisition and in long term learning retention.

Conclusion: In light of measurable results and significant p-values. A noteworthy contrast was observed in the knowledge acquisition test, and in knowledge retention assessments of the students allocated by PowerPoint and Prezi instructions. The consequences of the distinctive sorts of test showed that Prezi was a more viable instructional software for learning securing.

Keywords: PowerPoint, Prezi, Multimedia presentation, learning performance