Nowsherwan, Amjad Ali, Anwar Ali, Atta Muhammad, Mohammad Khalid Khan

Effectiveness of Terlipressin and Albumin for the Treatment of Hepatorenal Syndrome

Nowsherwan, Amjad Ali, Anwar Ali, Atta Muhammad, Mohammad Khalid Khan



Objective: To determine the effectiveness of terlipressinand albumin in the treatment of hepatorenal syndrome.

Study Design:Randomized control trial.

Place and Duration of Study: Study was conducted at Medical department of Lady Reading Hospital MTI Peshawar for duration of one year from 1stNovember, 2019 to 30thOctober 2020.

Methodology: Ninety six patients of both genders were enrolled in this study. Patient’s detailed demographics including age, sex, body mass index were recorded. They were divided into two equal groups; Group I patients received terlipression with albumin while in Group II patients received only albumin. Effectiveness of both medications was examined. Patients were followed for 14-days.

Results:There were 27 (56.25%) females and 21 (43.75%) males in group I with mean age of the patients were40.46±5.64 years while in group II females were 25 (52.08%) and males were 23(47.92%) with mean age 42.55±5.15 years. Mean BMI of the patients in group I was 24.22±6.18kg/m2 but in group II mean BMI was 23.61±6.42 kg/m2.Effectiveness in group I was 39 (81.25%) while in group II was 24 (50%).No significant difference was observed regarding 3-months mortality rate with p value <0.05.

Conclusion:We concluded in this study that the terlipression with albumin had higher effectiveness as compared to albumin alone.

Keywords: Hepatorenal Syndrome, Terlipression, Albumin, Effectiveness

Copyright © Pakistan Journal of Medical & Health Sciences 2024. All rights reserved!