Zaeem Sibtain, Salman Taj Uppal, Muhammad Affan Qaiser, Muhammad Kamran Yousaf, Syed Hammad W. Talha Shah, Nazish Butt

Advances in Colonoscopy for Colorectal Cancer Screening: A Comparison between Chromocolonoscopy Vs Colonoscopy

Zaeem Sibtain, Salman Taj Uppal, Muhammad Affan Qaiser, Muhammad Kamran Yousaf, Syed Hammad W. Talha Shah, Nazish Butt



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ABSTRACT

Aim: A comparison between chromocolonoscopy versus white light colonoscopy in screening colorectal cancer

Methods: Patients were randomly assigned to high-definition white light colonoscopy (HDWLC) and high-definition chromocolonoscopy (HDCH). The patients were divided into two groups, each had 110 individuals

Results: An adenoma affected 1.2 to 2.1 patients on average, while polyps affected 1.4 to 1.9 patients on average, with an adenoma affecting 0.5 to 1.0 patient on average. Both the number of patients with at least one adenoma (54.5% vs. 47.2%, absolute difference 7.3%, 95% confidence interval (p value <0.01) and the number of adenomas per patient (1.2 versus 1.0, P <0.01) were slightly higher in the chromocolonoscopy group. Adenomas that had progressed by 10 mm or more differed from those that had progressed by <10 mm (0.16 versus 0.14, P = 0.4), although the differences were not statistically significant. In each group, one invasive malignancy was discovered, and it wasn't a benign tumor or neoplasm. By chromocolonoscopy, non-neoplastic lesions (1.9 per patient versus 1.1 per patient, P = 0.01) were detected significantly more frequently than adenomas larger than 5 mm in diameter (0.9 per patient versus 0.8 per patient, P < 0.01)

Conclusion: When compared to high-definition white light colonoscopy, high-definition chromocolonoscopy had a marginally greater rate of adenoma diagnosis and a moderate increase in flat adenomas and small lesions but not in large lesions. When it came to more advanced malignancies, both techniques produced the same results.

Keywords: Colorectal cancer, chromocolonoscopy



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