Aim: The use of stem cells in dental implant site development
Methods: A total of 15 patients were enrolled and
divided into three groups, with each group receiving 1x105, 1x106,
and 1x107 stem cell treatment dosages. Following treatment, CT scan
was done to measure their bone mineral density (BMD), which was scored using
Hounsfield units (HU) grading. Tests were performed prior to treatment, as well
as 4,6,8,12 weeks after dental implantation to determine the success of the
Results: There were no major side effects over the
six-month study period. There was no association identified between the stem
cell transplant and any of the side effects Multiplex immunological tests were
used to determine the amount of cytokines and chemokines present in the subjects.
The inflammatory markers eotaxin, FGF2, MCP-1, MDC, and IL17a were elevated in
patients treated with stem cells. Stem cells secrete cytokines and chemokines
that aid in the healing of damaged tissue.
Conclusions: Stem cell treatment for dental implantation
is well tolerated and has no significant negative effects.