Aim: To assess psychiatric
co-morbidity (i.e., depression and anxiety) and its associated risk factors
among Multidrug/Rifampicin Resistant Tuberculosis
was an analytical cross-sectional study carried out in Department of Chest
Medicine, Jinnah Post Graduate Medical Centre from February to August, 2015. Eighty
diagnosed and registered patients of MDR/RR-TB, able to comprehend Urdu
language, between the age range of 18 to 60 years were approached by using
convenient sampling technique. Psychiatric co-morbidity i.e., depression and
anxiety were assessed by using the Urdu adapted version of Patient Health
Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD – 7).
Results: By applying the standard
cut off score of 10 or more on PHQ-9 and GAD-7, the frequency of depression was
58 (72.5%) and for anxiety it was 53 (66.25%) out of 80 MDR/RR-TB patients.
The multivariant analysis, intensive phase of TB treatment (OR = 3.02; 95% CI =
0.97-9.41) was found to be significantly associated with depression by using
PHQ-9 and age group of 18 to 30 years (OR=0.156; 95% CI= 0.02-0.86), pulmonary
TB (OR=6.33e+7; 95% CI=0.00-inf) and intensive phase of treatment (OR= 3.892;
95% CI=1.14-13.20) were significantly associated with anxiety by using GAD-7.
of psychiatric co-morbidity was higher among MDR/RR-TB patients. Age group of
18 to 30 years, pulmonary TB and intensive phase of treatment were found to be
the risk factors for depression and anxiety among TB patients. Psycho-social
factors are strong factors in the successful treatment of tuberculosis. Early
detection and proper management of psychiatric co-morbidity during the
treatment of MDR-TB needs special attention.
Keywords: Anxiety, Depression, Drug resistance, Multidrug resistance tuberculosis, psychiatric co-morbidity,