ABSTRACT

 Aim: To determine the effect of zinc on spermatogenesis

Methodology: the study was done at Shahida Islam Medical Complex, Lodhran. 60 albino rats were selected and divided into 4 groups each consisting of 15 albino rats each. The first control group-1 was feed with normal diet, while the group-2 and group-3 were treated with indomethacin and zinc respectively. Whereas the group-4 was treated with both zinc and indomethacin. This intervention was carried out for 12 weeks. Once the study was concluded, the rats were euthanized and histopathological analysis of the testes was carried out to determine the effect on spermatogenesis.

Results: group 4 showed favorable results in which normal spermatogenesis could be observed, in group 2 however, focal loss of germ cells series was seen as well as focal basement membrane detachment.

Conclusion: the study can safely say that zinc metal exhibits a protective role on the testes of albino rats

Keywords: Spermatogenesis, Albino rats, Zinc, Indomethacin, Sertoli cells