Amber Shami, Muhammad Bahadur Baloch, Attiya Mubarik Khalid, Fouzia Farzana, Maryam Nasim, Muhammad Muneeb Ather

Hepatotoxic Potential of Doxorubicin in Albino Rats

Amber Shami, Muhammad Bahadur Baloch, Attiya Mubarik Khalid, Fouzia Farzana, Maryam Nasim, Muhammad Muneeb Ather



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ABSTRACT

Background: Doxorubicin is an effective chemotherapeutic drug, but its toxic potential limits its use.

Aim: To study the effects of doxorubicin on the relative tissue weight index and hepatic central vein diameter in the albino rats.

Study Design: Experimental study 

Place and Duration of study: Study was conducted on 20 adult albino rats of both male and female gender in the animal house of Anatomy department, (PGMI) Lahore, Pakistan in April 2019.

Materials & Methods: Twenty, healthy adult albino rats of either sex, aging 6 to 8 weeks with 180-220 g of weight were randomly allotted to two groups A and B, each group having ten animals. Standard Rat feed and distilled water were given intraperitonially in the dose of 1.2mg/kg/body weight to the control group whereas doxorubicin was given intraperitoneally in the dose of 1.2mg/kg/body weight to the experimental group twice a week for 21 days. Body weight along with relative Tissue Weight Index were measured in gms at the end of the experiment. Diameter of central vein (┬Ám) was assessed histologically.

Results: The mean weight of the liver decreased significantly in the experimental group. On the contrary, the relative tissue weight index in all groups were significantly different according to the One-way-ANOVA test. The increase in the diameter of the central vein in the drug administered group commenced on significant basis (p-value < 0.001)

Conclusion: Doxorubicin has toxic effect on the relative tissue weight index and hepatic central vein diameter in the albino rats

KeyWords: Doxorubicin, Liver weight, relative tissue weight index, Central vein diameter, Liver, Hepatoxicity, Albino rats



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