Background: The female
reproductive organs include uterus, fallopian tubes and ovaries, these organs
when exposed to drugs and metals lead to anatomical damage resulting in
Researchers have documented the harmful
effects of the favorable antidepressant Lithium Carbonate on many human
viscera’s but even today the medicinal
world has scarce knowledge of the ablation
of ovarian anatomy by lithium carbonate.
Aim: To study and document the results of the
detrimental effects of Lithium on the ovaries.
Methods: We selected Twenty four adult
female rats for this observational and experimental study. The female albinos
were divided into two groups. Twelve animals were present in Group A and Group
B consisted of twelve female rats. The hygienically prepared laboratory diet
which consisted of flour pellets and green vegetables was given to Group A
animals and Group B rodents received Lithium carbonate in powder form for eight
weeks. After completion of the study time animals were sacrificed and weight of
ovaries were recorded and compared in both groups.
Results: The results in Group B documented
that animals had a highly significantly decline in ovarian weight after chronic
Lithium carbonate than in Group A.
prospective study concluded that chronic administration of Lithium
Carbonate causes distortion of its
tissue and highly significant decrement of weight of the ovary.
Keywords: Ovary, decrement, infertility