the COVID-19 pandemic has started, glucocorticoids have been proved to be one
of the most effective lifesaving treatments for respiratory complications
associated with SARS CoV-2.
Aim: To review
the incidence of steroid induced diabetes and the associated risk factors in
Study Design: Retrospective cohort study
Place and duration of the study: Bahria International Hospital Lahore from 15th
April 2020 to 31st December 2020
Methodology: Two hundred and thirty patients of COVID-19 cases treated with
glucocorticoids (Dexamethasone 4mg BID) were enrolled. All known cases of
pre-existing diabetes mellitus and with initial (admission) random blood
glucose levels of more than 200 mg/dl were excluded. Patients labelled as
glucocorticoid induced diabetes mellitus (GI-DM)met the following criteria,
fasting blood glucose level of more than 126 mg/dl or a random glucose level of
more than200 mg/dlon two occasions after starting these patients on steroids.
glucocorticoid induced diabetes mellitus was 36 (15.65%). Multivariate logistic
regression analysis revealed that older age (odds ratio 1.19, 95% confidence
interval (1.02-1.36) was found to be the most profound risk factor for GI-DM.
induced diabetes mellitus found to be associated with glucocorticoid used among
COVID-19 patients especially in older ages. So, it is recommended that the
treating physicians should consider this side effect of steroids especially
when dealing with geriatric cases.
COVID-19, Steroids, SARS-CoV-2, Diabetes mellitus, Steroids induced diabetes,