M. Asim Rana, Mujtaba H. Siddiqui, Sitara Raza, Kinza Tehreem, M. F.Ullah Mahmood, M Javed, M. Ahad Qayyum, M. M. Hafeez

Incidence of Steroid-induced Diabetes in COVID-19 patients

M. Asim Rana, Mujtaba H. Siddiqui, Sitara Raza, Kinza Tehreem, M. F.Ullah Mahmood, M Javed, M. Ahad Qayyum, M. M. Hafeez



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ABSTRACT

Background: Since the COVID-19 pandemic has started, glucocorticoids have been proved to be one of the most effective lifesaving treatments for respiratory complications associated with SARS CoV-2.

Aim: To review the incidence of steroid induced diabetes and the associated risk factors in COVID-19 patients.

Study Design: Retrospective cohort study

Place and duration of the study: Bahria International Hospital Lahore from 15th April 2020 to 31st December 2020

Methodology: Two hundred and thirty patients of COVID-19 cases treated with glucocorticoids (Dexamethasone 4mg BID) were enrolled. All known cases of pre-existing diabetes mellitus and with initial (admission) random blood glucose levels of more than 200 mg/dl were excluded. Patients labelled as glucocorticoid induced diabetes mellitus (GI-DM)met the following criteria, fasting blood glucose level of more than 126 mg/dl or a random glucose level of more than200 mg/dlon two occasions after starting these patients on steroids.

Results: The glucocorticoid induced diabetes mellitus was 36 (15.65%). Multivariate logistic regression analysis revealed that older age (odds ratio 1.19, 95% confidence interval (1.02-1.36) was found to be the most profound risk factor for GI-DM.

Conclusion: Glucocorticoid induced diabetes mellitus found to be associated with glucocorticoid used among COVID-19 patients especially in older ages. So, it is recommended that the treating physicians should consider this side effect of steroids especially when dealing with geriatric cases.

Keywords: Hyperglycaemia, COVID-19, Steroids, SARS-CoV-2, Diabetes mellitus, Steroids induced diabetes, Glucocorticoids



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