Background: Nephrotoxicity is characterized by raised serum urea and creatinine
levels and kidneys being one of the primary organs of drug concentration
and excretion are vulnerable to many widely used marketed drugs, including
anti-cancer drugs, antibiotics, immunosuppressants, and radio contrast agents,
determine the nephroprotective effect of ethanolic extract of Carica papaya seeds
in Aminoglycoside induced acute nephrotoxicity. Study design: Quasi Experimental study.
Sprague Dawley rats were sub divided into 3 groups i.e., I, II and III with 10
rats in each group. Group II and III were administered Aminoglycoside drug;
Gentamycin in 80 mg/kg) via intraperitoneal route once daily for 5 consecutive
days to induce acute nephrotoxicity. At day 6, nephrotoxicity was confirmed by
measuring serum urea and creatinine. Ethanolic extract of Carica papaya seeds
(1000 mg/kg) was started once daily through oral route in group III for 5
consecutive days to see the nephroprotective effects of seed extract after
causing acute kidney injury. All animals were given standard diet pellets
manufactured at NIH.
serum urea and creatinine for Group I (Control Group) at day 0 were 24.90 mg/dL ± 1.633 and .750 mg/dL ± .0619 respectively.
Mean serum urea and creatinine for Group II (Disease Control Group) was 81.00 mg/dL ± 1.247 and 1.980mg/dL ± .0467 at day
6th. This suggested induction of nephrotoxicity by Gentamycin. Mean serum urea
and creatinine for Group III (Ethanolic Extract Treated Group) at 11 day was 72.40mg/dL± .991 and 1.680 mg/dL± .0467 after 5
days treatment with ethanolic extract of Carica papaya seeds.
We concluded that ethanolic extract of Carica
papaya seeds has significant nephroprotective effects on Aminoglycoside
induced acute nephrotoxicity in rats.
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