Aim: To compare
metformin vs insulin in Gestational Diabetes in terms of neonatal hypoglycemia.
Study design: Randomized controlled trial
/ Gynecology Unit-l, Holy Family Hospital, Rawalpindi.
Duration of study: 6 months i.e. 10-11-2017 to 10-05-2018
Data collection procedure: 240 patients were randomly allotted into two groups; A & B. Group A
received metformin and group B received regular insulin. Patient was admitted
at 36 wks onwards. Neonatal hypoglycemia was measured and entered in structured
Performa. All the data was entered and analyzed through SPSS version 22.
this study, the mean ± sd ages of patients were 28.7±5.05 years in insulin
group while 28.01±4.37years in metformin group. Mean neonatal blood sugar level
was 51.58±11.77mg/dl in insulin group while 57.37±10.61mg/dl in metformin
group. The difference was significant (p<0.05). In this study, neonatal
hypoglycemia was noted in 28 (23.3%) cases with insulin while in 1 (0.8%) case
with metformin. The difference was significant (p<0.05).
Conclusion: Metformin has better outcome than insulin in terms of less number of
Key words: Gestational
Diabetes, Metformin, Insulin, Neonatal Hypoglycemia