Background: Dyslipidemia or hyperlipidemia is a consequential condition resulting from
derangement in lipid profile. Standard
treatment such as Atorvastatin though beneficial, causes many
serious adverse effects thus an alternative like Crataegus oxyacantha (Hawthorn)
with hypolipidemic potential was investigated.
Aims: To evaluate prophylactic and therapeutic hypolipidemic potential of crataegus
(hawthorn) fruit in comparison with
atorvastatin in murine model of dyslipidemia through assessing physiological parameter i.e.,
weight and serum biochemical parameters i.e., lipid profile: TC, TGs, VLDL, LDL and HDL.
Study design: This experimental study was carried out in research laboratory
of Akhtar Saeed Medical and Dental College and National
Health Research Centre (NHRC), Lahore
Methods: A murine study of 60 days was
conducted on 64 male albino Wistar rats (Age ± 6 weeks) divided into 8 groups with 8 rats each weighing 180-200 grams. Group 1
(healthy control) received normal diet and 2 ml of normal saline for 60 days.
Group 2 (disease control) received HFD and 2 ml of normal saline for 30 days
while 3-5 (prophylactic groups) were given HFD along with ethanolic extract of Crataegus
oxyacantha fruit, atorvastatin and their combination in doses of 40 mg/kg
OD, 80 mg/kg OD and 20+40 mg/kg OD orally respectively for the same period. 6-8
(therapeutic groups) received ethanolic extract of Crataegus oxyacantha
fruit, atorvastatin and their combination respectively after induction of
dyslipidemia from 30th till 60th day in the same doses as
mentioned above. Each rat was
weighed and fasting samples for biochemical parameters were drawn by cardiac
puncture in all groups at baseline and repeated at 30th day in all groups while also at 60th day in therapeutic groups as well as healthy control
group. The results were analyzed using one way ANOVA for Mean±SD, post hoc
Tukey’s test for group comparison in the Graph-Pad Prism (V.5) software. A
p-value ≤ 0.05 was considered as statistically significant.
Study period: This study was conducted from September,
Results: Our murine study concludes that Crataegus
oxyacantha (40 mg/kg OD orally) when administered prophylactically and
therapeutically shows a noteworthy hypolipidemic
potential when compared with Atorvastatin
(80mg/kg OD orally). Better results were obtained in prophylactic doses as well as in low dose combination with Atorvastatin (20 mg/kg + 40
Conclusion: Results suggest that Crataegus
oxyacantha can be used as alternative in treating
Keywords: Crataegus oxyacantha, Atorvastatin, Hyperlipidemia.