Vitamin D Deficiency in Patients with Hypothyroidism
S H Memon, F Memon, Arshad H Abro, S Z A Shah, B R Devrajani, T Devrajani, A Memon, A Talpur, S Raza
Aim: To determine the Vitamin D deficiency in patients with hypothyroidism
Methods: A total of fifty patients clinically presented as hypothyroidism were recruited and included in the cross sectional descriptive study conducted from Jan-2018 to March-2018 at tertiary care teaching hospital Hyderabad. The inclusion criteria were the the hypothyroid subjects [(newly diagnosed hypothyroidism (TSH>15mU/l)] of age>20 years and either gender while the exclusion criteria were the patients The exclusion criteria of the study were known cases of thyroid malignancy, chronic kidney and liver disease, the patients already on hormone replacement therapy, known cases of ovarian and uterine malignancy and the patients already on medications as iodide, amiodarone, salicylates, propranolol, anti-epileptic drugs, lithium and corticosteroids and vitamin D supplements. The relevant and specific investigations were advised and 2 ml venous blood was taken after aseptic measure and sent to laboratory for serum vitamin D level. The frequency and percentages were computed for categorical variables whereas the mean ± SD was computed for numerical variables.
Results: During three months study period total fifty patients with hypothyroidism were recruited and studied had mean age ± SD identified as 58.93±7.61 (yrs). Regarding gender male 15 (30%) and female 35 (70%), diabetes mellitus 25 (50%), the residence as urban 20 (40%) and rural 30 (60%), hyperlipidemia 32 (64%), hypertension 28 (56%), vitamin D deficiency 36 (72%) while the co-morbids as obesity 20 (40%), osteoporosis 26 (52%) and asthma / COPD 11 (22%).
Conclusion: The vitamin D deficiency was observed in subjects with hypothyroidism; the high proportion of severe vitamin D deficiency identified in anti-TPO positive individuals than anti-TPO negative individuals.
Keywords: Vitamin D and Hypothyroidism