Afsheen Akbar,, Maryam Raza,,Amtul Huda,Sadia Zia, Shaheena Naz, Aasma Nighat Zaidi, Zulfiqar Ali
Pakistan Journal of Medical & Health Sciences




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Reduction in Glomerular Filtration Rate Following Live Kidney Transplant Donor

Afsheen Akbar,, Maryam Raza,,Amtul Huda,Sadia Zia, Shaheena Naz, Aasma Nighat Zaidi, Zulfiqar Ali



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ABSTRACT

Aim: Renal replacement therapy is best possible treatment for end stage renal failure, but current research suggestive of augmented long-term risk in renal function for the donor.

Methods:At this time, we evaluate the subjects for the risk of decreased (eGFR) estimated glomerular filtration rate within old 50 giver, who undergo pre-donation assessment and live benefactor nephrectomyamong 2007 and 2015by multiple centers of Pakistan.

Results:The mean pursuepoint in time was 8.5 years (0.9–28.2). Inco relational analysis, subject age and status of hypertension (arterial) by thereference line were considerablylinked witha elevatedhazard of unfavorable renal effect, in particular, eGFR <60mL/min/1.73m2 (age/year: hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.04–1.08, (HTN): HR 1.09, 95% CI 1.21–4.0), eGFR <60 mL/min/1.73 m2 and a turn down of _39% from the initial measured line (age: HR 1.07, 95% CI 1.03–1.13,HTN: HR 4.22, 95% CI 1.71–10.35), and, eGFR <45mL/min/1.73m2. Age and HTN HR 2.13, 95% CI1.04–1.21, HR 4.05, 95% CI 1.47–18.15 respectively, Adding together, eGFR levels at occasion of contribution was linked with a lesserhazard of eGFR <60 mL/min and eGFR <40 mL/min. The only significantpredictor for adverse renal outcomes was Age.

Conclusion: Arterial hypertension, lower level of eGFR, and age at the time of donation are powerful prognosticating factor for undesirable kidney adverse effects in live renaldonor.

Keywords: eGFR (per mL/min/1.73 m2) Estimated glomerular filtration rate, arterial hypertension HTN; ESRD



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