Background: HIV treatment centres register HIV positive patients, specially trained
doctors prescribe Antiretroviral Therapy to the selected cases that fulfill the
criteria for initiation of HAART.
establish predictive markers of failure of 1st line ART in HIV
positive patients on first line ART under treatment in HIV Treatment Centre of
Study design: Retrospective case control study.
Methodology: Retrospective case control study done at HIV
Treatment Centre at PIMS Islamabad. Cases were patients who failed 1st
line ART and started on second line ART from November 2005 to June 2020.
Patients responding well to first line ART since more than five years or more
were taken as controls. Various factors were analyzed in both groups and
compared to find their level of significance. Data was analyzed by SPSS
software, version 25 as qualitative
variables were expressed as frequencies and percentages.
Results: CD4 count of all 38 patients was below 300 on
diagnosis. In 21 patients (55.3%) CD4 count initially increased but there was
no rise in CD4 count in 17 patients (44.7%) after start of 1st line
Conclusion: We concluded that CD4
count is one of the most important predictive markers in success or failure of
ART. Rising number of CD4 count on follow up visits gives a strong indication
that patient is responding well to the prescribed treatment and is likely to
benefit from the current regimen of ARVs for a longer period in future.
Keywords: Predictive Markers, CD4 count, Viral Load,
HIV, ART, Compliance and Co-morbidities.