Ovulation Induction in Polycystic Ovarian Syndrome (PCO) Related Subfertility
Salma Zaman, Huma Arshad, Sarah Hafeez, Sara Rasul, Anosha Khan, Misha Khan
Aim: To compare clomiphene citrate and letrozole in cases with poly cystic ovarian syndrome.
Study design: Comparative trial
Place and duration of study: Department of Obstetrics & Gynaecology, Services Institute of Medical Sciences Lahore from 1st July 2020 to 31st December 2020.
Methodology: Two hundred females coming in subfertility clinic with 20-35 years of age range with confirmed diagnosis of polycystic ovarian syndrome were enrolled. They were divided in two equal groups. Each group received corresponding treatment starting on 2nd day of menstrual cycle for 5 days. Ovulation induction was assessed by follicle size on TVS at 14th day of cycle. In patients with successful ovulation induction, 5000 IU of human chorionic gonadotropin ((HCG) was given. Successful conception was assessed.
Results: The successful ovulation was done observed in 56 (56%) in Group A and 81 (81%) in Group B (p=<0.000) whereas successful conception was in 9 (9%) in Group A and 23 (23%) in Group B (p=<0.001).
Conclusion: Letrozole is significantly effective in terms of ovulation induction and conception in PCO
Keywords: Poly cystic ovarian, Clomiphene citrate, Letrozole ovulation induction, Conception