Serum Uric Acid in Relation with Insulin Resistance Associated Indices in Metabolic Syndrome
Uzma Zafar, Zaima Ali, Shaheena Naz, Afshan Iftikhar, Saba Khaliq, Khalid Lone
Aim: To check the correlation of serum uric acid and the indices associated with insulin resistance in metabolic syndrome and healthy male subjects. Insulin resistance associated indices in the current study were; blood pressure, waist-circumference (WCF), body mass index (BMI), waist- hip proportion, triceps skinfold thickness (TSFT), mid arm circumference (MACF), serum glucose and insulin.
Methodology: It was an observational and correlational study; including 200 subjects 120 with Met S and 80 healthy controls. A questionnaire was filled which included demographic details, previous and present history, drug information, physical and anthropometric parameters. 5.0 ml blood was taken from an approachable vein of the upper limb with aseptic manner. It was secured in properly marked vacutainers for determination of the biochemical parameters.
Results: Blood-pressure, WCF, waist- hip proportion, BMI, MACF, TSFT, serum insulin, glucose, uric acid and HOMA-IR were higher considerably in the cases than the controls. On spearman test; serum uric acid correlated significantly and directly with the BMI, MACF, TSFT, WCF and diastolic blood pressure in the controls. Significant positive correlation between serum uric acid, glucose and HOMA-IR was observed in the cases.
Conclusion: In this current narration positive linear correlation of serum uric acid and study variables incriminates the role of uric acid in insulin resistance and associated conditions such as metabolic syndrome, central obesity and altered glycemic metabolism. Raised levels of uric acid can be targeted as a curable risk element in the control of cardiovascular and metabolic derangements.
Keywords: Serum uric acid, insulin resistance, metabolic syndrome