Sudiyono1,2, Suharyo Hadisaputro2, Ari Suwondo2, Gunawan Santoso
Aim: to prove that young green coconut water (YGCM) reduces the risk of Contrast Induced Nephropathy(CIN) through the change of Tumor Necrosis Factor-α (TNF-α). Malondialdehyde (MDA).Neutrophil gelatinase-associated lipocalin (NGAL) and renal tubular cell histopathology.
Study Design: Experimental research with pre- and post-test control group design.
Method: As many 30 rats were randomly divided into 5 groups (K1-K5). Green coconut water was given for 3 (three) days after Iodine Contrast Media (IoCM) induction. Samples were measured at 2. 24 and 48 hours after injection.andrats mice were terminated with anesthesia and cervical dislocation. Examination of samples using ELISA and analyzed by Linier General Model (LGM). and Fisher Exact
Result: YoungGreen coconut water decreased TNF-α levels by 3.9% in K-1. 19.7% in K-2 and 2.8% in K-3. reducing MDA levels by 28.7% in K-1. 26.7 % for K-2 and 30.6% for K-3. The decreased also occurred in NGAN by 0.1% on K-1. 9.9% on K-2 and 6.8% on K-3. while the histopathological picture of renal tubular cells explained that there was no pathological change in K-1 and K-3. there is NET on K-2 and there is NIPV on K-4. Statistically. the difference in the effect of YGCM on the reduction of TNF-α. NGAL. MDA and histopathological changes between groups was not significant (p> 0.05).
Conclusion: Young Green Coconut Water lowers TNF-α. MDA. NGAL and potentially to be used on the risk of CIN prevention.
Keywords: Green coconut water.Iodine Contrast Media.Tumor Necrosis Factor-α.Malondialdehyde.Neutrophil gelatinase-associated lipocalin