Human Chorionic Gonadotrophine Level on Day, 7, 10, 14, Post-Embryo Transfer Following Day 3 Embryo Transfer can Predict Clinical Pregnancy in both fresh and frozen cycles
Wasan Fawzi Sanad1, Thuraya Hussanuldeen Abdulla2, Ula Alkawaz
Background: human chorionic gonadotropin (HCG),a hormone produced by placental trophoplastic cells, and it is the earliest marker to detect and evaluate pregnancy outcome, it can be detected in maternal serum as early as 6-8 days post embryo transfer, several studies have demonstrated its important role in establishing and maintaining pregnancy, and early development of the embryo, and development of embryo brain other important role BHCG in protocols of IVF cycles.
Aim: To measure BHCG as early as possible to detect if pregnancy achieved or not after embryo transfer in(ICSI) cycle and can predict result of pregnancy as early as 7th day and 10th and 14th day post embryo transfer.
Method: Observation study was conducted in Baghdad in October 2019 till October 2020 in high institute for infertility diagnosis and ART, and KAMAL AL SAMARIA Hospital Baghdad,50 lady were enrolled both fresh 72%and frozencycle28%had done (ICSI) cycle then measure (BHCG) in day 7, day 10, day 14 post embryo transfer in both fresh and frozen cycle, (BHCG) follow up to detect clinical pregnancy, follow up by vaginal ultrasound until 12 weeks of gestation
Result: BHCG titer in day 7 was significant P value 0.0001 comparing to day 10 and P value in day 7 was significant P value 0.0001comparing to day 14, BHCG titer in day 10 was significant P value 0.0001comparing to day 14, Pregnancy rate was 64%, NO ECTOPIC pregnancy. Miscarriage rate was 8% Pregnancy rate after fresh cycle was 58.3% & pregnancy rate after frozen cycle was 78.6%
• Cut of value in day 7 post embryo transfer is 17.496±17.66
• Cut of value for day 10 post embryo transfer was 44,774±42.93
• Cut of value for day 14 post embryo transfer was 454.27
Conclusion: Day 7 post embryo transfer BHCG titer was significant so it can be used to alleviate stress of the patient & can be used as early predictor of pregnancy. Day 10 post embryo transfer BHCG titer was significant it can be usedas indicator for pregnancy. DAY14 was significant post embryo transfer it can be used even before clinical pregnancy.
Keywords: Human chorionic gonadotropin, IVF cycles,