Fawad Nasurullah , Shams-Ul-Islam,Kamran Ziidi. Muhammad Waqas Hussain, Muhammad Haider
Aim:To determine the effect of coenzyme Q10 on
improvement of total sperm count and sperm motility in infertile men.
experimental Pilot study
ward, Mayo Hospital Lahore
nine married male patients aged 18-40 years who had failure to cause pregnancy
after 12 months or more of unprotected sexual intercourse with oligoasthenospermia
and normal blood serum FSH, LH, and total testosterone and normal external
genitalia were included and randomly divided into Treatment
group and Placebo group. Cases were given 200 mg CoQ10 once daily for 3
months and group B were given placebo (Ferrous
sulphate 200mg).Semen analysis was done at baseline and then after 3
months of treatment.
nine patients meeting
the inclusion criteria were included in this pilot study after written consent.
All of these cases were married and had BMI <30 (non-obese). Age ranged from
20 to 33 years with total sperm count (x106) at baseline was 30.8±
and after 3 months of treatments was 72.3±38.4 while sperm
motility at baseline was 29.6±18.6 and after 3 months of treatment was 50
26 in the treatment group. The significant improvement in
the sperm count and motility (≥50% increase) in the treatment group noted in
this pilot study was 85.7% and 78.6%.
our pilot study, sperm count and sperm motility significantly improved after 3
months treatment with CoQ10. Further conclusions can be made when the trial
will be complete. This study should be extended further to follow patients till
a successful pregnancy and/or live birth.
Coenzyme Q, Infertility, Subfertility, Oligospermia,
Trial, Pilot study, Urology, Sperm count, Motility