Comparison of Positive Predictive Value of Multiphasic Dynamic Contrast Enhanced MRI with Dynamic Contrast Enhanced CT for the Detection of Hepatocellular Carcinoma
Sana Akhtar, Madeha Hussain, Sadia Ali, Saba Maqsood, Saba Akram, Najaf Abbas
Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide (1), developing within a cirrhotic background in up to 90% of cases. HCC has a 5-year survival rate of less than 10% as it is an aggressive and rapidly growing tumor.
Aim: To compare the positive predictive value of DCEMRI (dynamic contrast enhanced MRI) with DCECT (dynamic contrast enhanced CT-Scan) in the diagnosis of Hepatocellular carcinoma.
Methods: This comparative study was carried out on one hundred patients (Mean age, 52 years; age range, 36–80 years) who fulfilled the inclusion criteria. Fifty patients were included in each groups (CT, MRI). CT/ MRI findings of intense arterial uptake followed by a ‘‘washout’’ of contrast in the venous-delayed phases was taken as suspicion of HCC. Histopathology was taken as a gold standard for diagnosis.
Results: Out of 100 patients, 61 patients (61%) were males while 39 patients (39%) were females. The age of the patients ranged from minimum age of 36 years to maximum age of 80 years with a mean age of 52 years. The positive predictive value of dynamic contrast enhanced MRI was 94%, while that of dynamic contrast enhanced CT-Scan was 86%.
Conclusion: Dynamic contrast enhanced MRI (DCEMRI) is a superior modality for diagnosis of hepatocellular carcinoma as compared with dynamic contrast-enhanced CT-scan (DCECT).