Aim: To determine
the diagnostic accuracy of Plasma lactate and C-reactive protein in patients
with acute appendicitis taking histopathology as gold standard.
Methodology: This study was conducted in department of Chemical Pathology, PGMI
Lahore. Duration of study was one
year. 200 suspected cases of acute appendicitis were included. Patients were
categorized as with and without acute appendicitis on the basis of Lactate and
c- reactive protein levels taking histopathology as gold standard. Sensitivity,
specificity, positive predictive value, negative predictive value of Lactate
and C-reactive protein were calculated.
mean plasma lactate levels were higher in patients with acute appendicitis when
compare with subjects with no histological evidence of acute appendicitis, (p
<0.001). The sensitivity and specificity of Lactate assessed by ROC curve
analysis were 90.9% and 91.7%, respectively. In 60 cases with appendicitis
57(95%) had CRP ≥ 6 mg/dl while 3(5%) had CRP level < 6mg/dl. In 60 cases
without appendicitis 6(10%) cases had CRP ≥ 6mg/dl and 54(90%) cases had < 6
mg/dl CRP. There was a significant (≥6) among cases with and without
appendicitis, p-value ≤0.001. The sensitivity, specificity, positive predictive
value and negative predictive value of CRP for diagnosis of acute appendicitis
were 95%, 90% and 95%, respectively.
Conclusions: The Lactate and CRP have a good diagnostic accuracy for
acute appendicitis and can be used as an alternate in patients suspected of
Diagnostics trail, C-reactive protein, Lactate, Histopathology