is a treatment of choice in patients who intend to achieve pregnancy in future.
One of the important challenges in myomectomy is intra and post-operative
Aim: To assess the efficacy of
pre-operative rectal administration of misoprostol on the intra and
post-operative bleeding in patients with intramural myoma.
Methods: A total of 94
women who were candidate for myomectomy were randomly enrolled in this clinical
trial. The intervention group received 400 µg misoprostol rectally one hour
before myomectomy.Hemoglobin and hematocrit were assessed in both intervention
and control groups 4 and 24 hours after surgery. Furthermore, bleeding volume,
duration of surgery, duration of admission, complications, need for transfusion
and hysterectomy were assessed for both groups.
Results: The findings of
this study revealed that pre-operative administration of 400 µg misoprostol
resulted in a significant reduction in bleeding (p<0.001) but did not affect
duration of surgery and admission, as well as complications, transfusion
requirement, hysterectomy or hemoglobin and hematocrit levels 4 and 24 hours
after surgery (p>0.05).
rectal administration of 400 µg misoprostol resulted in reduction in intra-operative
bleeding in patients with intramural myoma.