Compare the Efficacy of 0.2% Topical Glyceryl Trinitrate (GTN) Versus Placebo in Prevention of Wound Infection in Patients Undergoing Milligan-Morgan Hemorrhoidectomy
Khumair Asif, Maaz-Ul-Hassan, Pir Muneeb Rehman, Tayyaba Rasheed, Laiba Zahid
Objective: To examine the efficacy of 0.2% topical glyceryltrinitrate and compare with placebo for prevention of wound infection after Milligan Morgan hemorrhoidectomy.
Study Design: Randomized controlled trial
Place & Duration of Study: Department of Surgery, AkhtarSaeed Medical & Dental College Lahore from 1st July 2019 to 31st December 2019.
Methods: One hundred and ten patients of both genders with ages 20 to 65 years were enrolled and divided into two groups (each group contains 55 patients). Group I received of 0.2% topical glyceryltrinitrateointment and Group II received placebo. Postoperative wound infection was examined at 2 weeks postoperatively. Compare the wound infection rate between both groups.
Results: There were 68 (61.82%) male patients and 42 (38.18%) were females with mean age 34.62±12.46 years. 60 (54.55%) patients had 4th degree hemorrhoidal disease and 50 (45.45%) patients had 3rd degree disease. In group I 8(14.55%) patients had developed wound infection while in group II 30 (54.55%) patients had developed wound infection, a significant difference was observed between both groups with p-value <0.05.
Conclusion: It is concluded that 0.2% glyceryl trinitrate is better and safe treatment modality for the prevention of wound infection.