Umair Arif, Muhammad Rizwan Hafeez, Sibgha Bashir, Adil Mehmood, Rana Aatif Siddique, Saima Nasreen
Pakistan Journal of Medical & Health Sciences




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Examine the Frequency of Myocarditis and Associated Mortality in Patients with Paraphenylene Diamine Poisoning

Umair Arif, Muhammad Rizwan Hafeez, Sibgha Bashir, Adil Mehmood, Rana Aatif Siddique, Saima Nasreen



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ABSTRACT

 

Aim: To determine the frequency of myocarditis and associated mortality in patients presented with paraphenylene diamine (PPD) ingestion.

Study Design:Prospective/observational study

Place & duration: Department of Medicine Shahida Islam Medical & Dental College Lodhran from 1st October to 31st October 2019.

Methods: One hundred adult patients of both genders presented with paraphenylene ingestion were enrolled in this study. Patients demographics including age, sex and reasons of ingestion of PPD were recorded after taking written consent from patients/attendants. Clinical presentation including sign and symptoms were recorded. Diagnosis of myocarditis was made solely on the basis of the clinical signs/symptoms suggestive of myocardial damage, electrocardiography changes, elevated cardiac biomarkers and abnormalities on trans-thoracic echocardiography. Mortality associated with myocarditis was examined.

Results: Eighty two (82%) were females while 18% were males. The mean age of patients was 27.25±7.48 years. Suicide was the most common reason of ingestion of PPD found in 94% cases. Cervico-facial edema was the commonest symptom found in 85% cases. Myocarditis was found in 21 (21%) patients. From 21 myocarditis patients 8 (38.10%) patients were died. Overall mortality rate was 28%.

Conclusion: Myocarditis is highly associated with praphenylene diamine ingestion with high rate of mortality.

Keyword: Paraphenylene diamine poisoning, Myocarditis, Mortality

 




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