Aim: To determine the frequency of myocarditis and
associated mortality in patients presented with paraphenylene diamine (PPD)
Study Design:Prospective/observational study
Place & duration: Department of
Medicine Shahida Islam Medical & Dental College Lodhran from 1st
October to 31st October 2019.
Methods: One hundred adult patients of both
genders presented with paraphenylene ingestion were enrolled in this study.
Patients demographics including age, sex and reasons of ingestion of PPD were
recorded after taking written consent from patients/attendants. Clinical
presentation including sign and symptoms were recorded. Diagnosis of myocarditis
was made solely on the basis of the clinical signs/symptoms suggestive of
myocardial damage, electrocardiography changes, elevated cardiac biomarkers and
abnormalities on trans-thoracic echocardiography. Mortality associated with
myocarditis was examined.
Results: Eighty two (82%) were females while
18% were males. The mean age of patients was 27.25±7.48 years. Suicide was the
most common reason of ingestion of PPD found in 94% cases. Cervico-facial edema
was the commonest symptom found in 85% cases. Myocarditis was found in 21 (21%)
patients. From 21 myocarditis patients 8 (38.10%) patients were died. Overall
mortality rate was 28%.
Conclusion: Myocarditis is
highly associated with praphenylene diamine ingestion with high rate of
Keyword: Paraphenylene diamine poisoning,