Muhammad Rizwan Hafeez, Sibgha Bashir, Umair Arif, Adil Mehmood, Rana Aatif Siddique, Anas Ahmed Qureshi
Pakistan Journal of Medical & Health Sciences




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Examine the Association of Proton Pump Inhibitors with Iron Deficiency Anemia

Muhammad Rizwan Hafeez, Sibgha Bashir, Umair Arif, Adil Mehmood, Rana Aatif Siddique, Anas Ahmed Qureshi



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ABSTRACT

 

Aim: To determine the association of iron deficiency anemia in patients with proton pump inhibitors therapy.

Study design: Retrospective/observational study

Place & duration: Department of Medicine, Shahida Islam Medical College Lodhran from 1stJuly 2018 to 31st December 2019.

Methods: One hundred and fifty patients of both genders with ages 20 to 70 years presented with gastrointestinal diseases and advised to use proton pump inhibitors therapy were enrolled in this study. Patients detailed demographic including age, sex and residence were recorded after taking informed written consent. Serum ferritin level and iron level were examined at the beginning and at 8 months of PPI therapy.

Results:Eighty six (57.33) patients were males while 64(42.67%) were females with mean age 42.15±12.38 years. Majority of patients 90(60%) had urban residency. At beginning of treatment mean serum ferritin level was 68.72±30.41ng/ml and at 8 months it was 27.45±16.26ng/ml, a significant difference was observed with p-value <0.001. Mean iron level at start of treatment was 18.28±6.54umol/l and at 8 months it was 15.86±5.72umol/l. Iron deficiency anemia was found in 38(25.33%) patients at 8 months follow-up.

Conclusion: Iron deficiency anemia is highly associated with proton pump inhibitors therapy. The frequency of iron deficiency anemia was high at the end of treatment.

Keyword: Gastrointestinal disease, Proton pump inhibitors, Serum ferritin level, Anemia



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