Background: Guillianbarre’ syndrome is a polyradiculoneuropathy
that is usually acute and immune mediated, characterized by symmetric ascending
muscle weakness and areflexia.
Aims: To observe the frequency of respiratory failure along
with outcome in children with GBS.
Methods: This was a cross sectional, observational
study performed in thedepartment of neurology and intensive care unit of The
Children’s hospital and The Institute of Child Health, Lahore fromJanuary 2018
to December2018. A total of 100 children of both gender diagnosed as GBS, from
1-15 years of age were included in the study according to inclusion criteria.Signs
of respiratory failure and arterial blood gas were monitored in all patients,
and outcome of all patients who were put on mechanical ventilator were recorded
on a proforma.
Results: Out of 100 patients, most were males (62%). Mostly
patients were between 1-5 years of age (47%). Weakness of lower limbs,
hypotonia and areflexia were the most common presentations (100%), followed by
sensory symptoms (66%) and autonomic instability ( 58%).Respiratory failure
requiring mechanical ventilation was present in 12 % patients,9 of which were
weaned off the ventilator and 3 patients expired.
Conclusion: Neuromuscular respiratory failure requiring
mechanical ventilation is a usual complication of GBS ,that can lead to increased
mortality. Anticipation and early detection of signs of impending respiratory
failure can improve the outcome.
syndrome, Respiratory failure, outcome