Aysha Mansoor Lodhi, Asma Mushtaq, Javeria Nayyar, Muhammad Shehram, Muhammad Nasir Rana
Pakistan Journal of Medical & Health Sciences

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Clinical Spectrum and Sensitivity Pattern of Isolates in Pediatric Febrile Neutropenic of Acute Lymphoblastic Leukemia

Aysha Mansoor Lodhi, Asma Mushtaq, Javeria Nayyar, Muhammad Shehram, Muhammad Nasir Rana




Aim: To determine the clinical spectrumand sensitivity pattern of isolates in pediatric febrile neutropenic patients of Acute Lymphoblastic Leukemia.

Methods: This descriptive observational study was conducted at Department of Pediatric medicine, The Children's Hospital, Lahore. A total of 100 patients between 01 to 15 years of

age who fulfilled the criteria of febrile neutropenia were included in the study. Data was

entered andanalyzed by SPSS 20.

Results: Out of 100 patients, 65(65%) were males while 35 (35%) were females. Forty fivewere between 1-5 years of age, 31between 6-10 years and 24were between 11-15 years of age. Majority (46%)presented with fever of unknown origin.Out of 160 cultures, 60 turned out to be positive. Highest yield was obtained from blood (45%). Forty eight were gram-negative (80%) while 9 were gram-positive bacteria (15%). Gram-negative bacteria were dominated by Klebsiella while Staphylococcus Aureus was the most frequently isolated gram-positive organism

The sensitivity pattern of Klebsiella against empirical antibiotic regimen revealed highest sensitivity with Meropenem (31%). Highest sensitivity of Pseudomonas was found for Tazobactum/Piperacillin (77%). Staphylococcus Aureus was found to be 100% sensitive to Linezolid and Vancomycin followed by Amikacin .

Conclusion: Fever of unknown origin was the most common presentation. Gram negative bacteria dominated the isolates. The current empiric antibiotic regime has shown promising results in sensitivity patterns and should be continued till further studies.

Keywords: Febrile Neutropenia, Acute Lymphoblastic Leukemia, Antibiotics, Sensitivity

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