determine the clinical spectrumand sensitivity pattern of isolates in pediatric
febrile neutropenic patients of Acute Lymphoblastic Leukemia.
Methods: This descriptive observational study was conducted at Department of
Pediatric medicine, The Children's Hospital, Lahore. A total of 100 patients
between 01 to 15 years of
age who fulfilled the
criteria of febrile neutropenia were included in the study. Data was
entered andanalyzed by SPSS
Results: Out of 100 patients, 65(65%) were males while 35 (35%) were females.
Forty fivewere between 1-5 years of age, 31between 6-10 years and 24were
between 11-15 years of age. Majority (46%)presented with fever of unknown
origin.Out of 160 cultures, 60 turned out to be positive. Highest yield was
obtained from blood (45%). Forty eight were gram-negative (80%) while 9 were
gram-positive bacteria (15%). Gram-negative bacteria were dominated by
Klebsiella while Staphylococcus Aureus was the most frequently isolated
The sensitivity pattern of Klebsiella against
empirical antibiotic regimen revealed highest sensitivity with Meropenem (31%).
Highest sensitivity of Pseudomonas was found for Tazobactum/Piperacillin (77%).
Staphylococcus Aureus was found to be 100% sensitive to Linezolid and
Vancomycin followed by Amikacin .
Conclusion: Fever of unknown origin was the most common
presentation. Gram negative bacteria dominated the isolates. The current
empiric antibiotic regime has shown promising results in sensitivity patterns
and should be continued till further studies.
Keywords: Febrile Neutropenia, Acute Lymphoblastic
Leukemia, Antibiotics, Sensitivity