Aim: To analyze the role of association of Vitamin D with HDL cholesterol
and HBA1c in diabetic patients
Study Design: Cross-sectional study
Place & Duration: Department of Medicine, Shahida Islam Medical College Lodhran from 1st
August 2018 to 30th November 2019.
Methods: One hundred diabetic
patients from the age range 20 to 60 years were included in this study. After overnight fasting, 10 ml of
peripheral blood was withdrawn. Blood samples were centrifuged at 3000 rpm
for 10 min and stored at -20°C. Serum levels of 25(OH) D, calcium and
fasting serum glucose was measured using Randox kit. Plasma total cholesterol,
HDL-C, and triglyceride concentrations were measured in duplicate using enzymatic
kits, standardized reagents, and standards.
Results: The mean age range of
57.5 years. 73.4% of the
patients were male, 26.6% were female respectively. The mean age of the
patients was 57.7±10. The mean HbA1c values of the patients were 9.18±2.52. The
mean vitamin D values of the patients were 9.17±3.7. The vitamin D deficiency
was in 98.3% of the patients. The collected parameters were compared
between good glycemic control patients (HbA1c≤7%) and poor glycemic control
Conclusion: High density lipoprotein correlation was found to be
prominent with vitamin D and hence conclusion was validated with respect to
HDL. Therefore, the relationship between serum levels of 25(OH) D and lipids
may be affected by increased disease duration in these patients.
Keyword: Diabetes, Diagnostic, Vitamin-D, LDL