Muhammad Rizwan Hafeez, Sibgha Bashir, Umair Arif, Adil Mehmood, Rana Aatif Siddique, Anas Ahmed Qureshi
Pakistan Journal of Medical & Health Sciences




Peer Reviewed

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A Comprehensive Study on Association of Vitamin D with HDL Cholesterol and HBA1c in Diabetic Patients

Muhammad Rizwan Hafeez, Sibgha Bashir, Umair Arif, Adil Mehmood, Rana Aatif Siddique, Anas Ahmed Qureshi



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ABSTRACT

 

Aim: To analyze the role of association of Vitamin D with HDL cholesterol and HBA1c in diabetic patients

Study Design: Cross-sectional study

Place & Duration: Department of Medicine, Shahida Islam Medical College Lodhran from 1st August 2018 to 30th November 2019.

Methods: One hundred diabetic patients from the age range 20 to 60 years were included in this study. After overnight fasting, 10 ml of peripheral blood was withdrawn. Blood samples were centrifuged at 3000 rpm for 10 min and stored at -20°C. Serum levels of 25(OH) D, calcium and fasting serum glucose was measured using Randox kit. Plasma total cholesterol, HDL-C, and triglyceride concentrations were measured in duplicate using enzymatic kits, standardized reagents, and standards.

Results: The mean age range of 57.5 years. 73.4% of the patients were male, 26.6% were female respectively. The mean age of the patients was 57.7±10. The mean HbA1c values of the patients were 9.18±2.52. The mean vitamin D values of the patients were 9.17±3.7. The vitamin D deficiency was in 98.3% of the patients. The collected parameters were compared between good glycemic control patients (HbA1c≤7%) and poor glycemic control patients (HbA1c>7%).

Conclusion: High density lipoprotein correlation was found to be prominent with vitamin D and hence conclusion was validated with respect to HDL. Therefore, the relationship between serum levels of 25(OH) D and lipids may be affected by increased disease duration in these patients.

Keyword: Diabetes, Diagnostic, Vitamin-D, LDL



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