Aim: To examine
the diagnostic importance of tumor necrosis factor alphain chronic hepatitis C infection with or without
Study Design:Prospective study
Place and Duration of study: Department of Gastroenterology, Bolan Medical
Complex Hospital, Quetta from 1st January 2019 to 30th
Methodology:Total 90 Patients of chronic hepatitis C were divided into two groups,
group I and II, Group I contains 45 patients with liver cirrhosis and group II
consist of 45 patients without cirrhosis. The ageof these patients were between
30 to 50 years. The clinical history and examination were done while blood and
liver biopsy samples were taken from all the patients and sent to the pathology
department for diagnosis of chronic hepatitis C infection and liver cirrhosis.
were 50(55.56%) male patients and 40(44.44%) female patients. Mean age of
patients 39.4±5.36. The serum TNF alpha was significantly higher in liver
cirrhosis 71.96±18.35 than the patients without cirrhosis that was 42.72±13.5
with p-value <0.0001.
of TNF alpha is a good and accurate predictor of chronic hepatitis C with and
without liver cirrhosis that would be essential to reduce the requirement of
liver biopsy among chronic hepatitis C patients.
Keywords:Tumor necrosis factor alpha, Hepatitis C
virus, Chronic hepatitis C, Liver disease