Aim: To detect the aspartate aminotransferase to platelet ratio index (APRI)
as a predictor of chronic hepatitis C infection with or without liver
Study Design: Prospective study
Place and Duration of
study: Department of
Gastroenterology, Bolan Medical Complex Hospital Quetta from 1st
October 2018 to 31stMarch 2019.
Methodology:Eighty patients of chronic hepatitis C were divided into groups. First
group of 41 patients having cirrhosis and second group consisted of 39 patients
without cirrhosis. The ages of these patients ware ranged between 34-42 years
with both genders. The clinical history and examination were done while blood
and liver biopsy samples were taken from all the patients and sent to the
pathology department for the diagnosis of chronic hepatitis C infection and
Results:The mean age was 38.2±4.2 years and male to female ratio was 1.3:1. The
APRI was significantly higher in liver cirrhosis than the patients without
cirrhosis that is 2.19±0.60 and 0.80±0.28 respectively.
Conclusion: Application APRI is a good and accurate predictor value of chronic
hepatitis C with and without liver cirrhosis that would be essential to reduce
the requirement of liver biopsy among chronic hepatitis C patients.
Keywords: Chronic hepatitis C, Liver cirrhosis, Alanine serum transferase,
Platelet ratio index, Predictor value