Aim: To determine
the vitamin D deficiency in COVID-19 infection and its association with the
severity and fatality of COVID-19 disease.
Study Design: Descriptive
cross sectional study
Place and duration of study: Department of Internal Medicine Bolan Medical College Hospital Quetta
from 1st March to 30th April 2020.
total of 168 patients diagnosed with COVID-19 infection, age ranged from 30 to
80 years of either gender were included. The brief medical history was taken
and clinical examination were done. Nasopharyngeal and oropharyngeal swabs
samples of patient for severe acute respiratory syndrome coronavirus 2 were
collected and sent to the hospital medical laboratory to detect COVID-19 infection by using real-time polymerase chain
reaction(RT-PCR). Blood sample of each patient were also collected to detect the vitamin
age of patients was 42.26±13.69 years, 94(56%) were males, while 74(44%) were
females. Most of the patients were with age group of 31-50 years 80(47.6%). Regarding
COVID-19 asymptomatic subjects were 139(82.73%), while 22(13.09%), 5(2.97%), 2(1.19%)
cases were respectively suffering from mild, moderate and severe disease. Vit D deficiency was significantly associated with
both asymptomatic and symptomatic cases.
D is having protective role in respiratory tract infections. Its administration
in deficient individuals suffering from COVID-19 infection may boost the immune
system and reduces the severity of COVID-19 infection Vitamin D supplementation
might boost the immune system of COVID-19 patients and reduce severity of the
disease in vitamin D deficient individuals.
acute respiratory syndrome coronavirus 2, Coronavirus disease 19, Real-time
polymerase chain reaction, Vitamin D; Angiotensin-converting enzyme 2,
Pneumonia; Acute respiratory distress syndrome