Background: Pre-term labour is a serious issue that
impact the both maternal and neonatal health. There is debate how to deal with
this issue and multiple options are utilized. In this study the tocolytic
action of nifedipine combined with sildenafil citrate (SC) versus nifedipine
alone in inhibiting threatened preterm labour (PTL) is evaluated so that a drug
of choice could be determined.
Methods: It was a randomized controlled trial carried
out in Sir Ganga Ram Hospital, Lahore for a duration of six months. Patients
were randomly allocated to receive either (1) nifedipine 20mg orally (stat
dose), followed by 10mg orally every 8 hours and at the same time oral
administration of SC (25mg at 8‐hourly intervals) or (2) nifedipine alone. Medications
were continued for 72 hours. The comparison of women who remained undelivered
during hospitalization and one week after admission, was made to determine the
best modality to prevent the threatened preterm labor.
Results: The baseline characteristics of participants
were similar (p-value>0.05).On comparison of the both treatment groups, it
was found that 121(82.9%) in the combination group and 103(70.5%) in the
nifedipine alone group remained un-delivered. (P-value<0.05). Moreover, a
significant difference was noted with respect to delivery at one week for both
Conclusions: Oral SC combined with nifedipine is an
effective option for tocolytic therapy for threatened PTL.
Keyword: Nifedipine, Sildenafil citrate, Pre-term delivery, Tocolytic therapy