Tanvir Ahmad Bhatti, Syed Muhammad Aftab Hassan, Hamid Khail, Wasim Ashraf, A J Awans, Sadaf Zahra Syyed

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Elevated levels of Alanine Transaminase (ALT) is an independent risk factor for Coronary Artery Disease (CAD)

Tanvir Ahmad Bhatti, Syed Muhammad Aftab Hassan, Hamid Khail, Wasim Ashraf, A J Awans, Sadaf Zahra Syyed



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ABSTRACT

 

Background: Coronary artery disease is the most common form of heart disease with multifactorial etiology and atherosclerosis. Recently it is considered that ALT associated with endothelial dysfunction and carotid atherosclerosis. The predictive value of ALT for coronary events seems independent of traditional risk factors and the features of the metabolic syndrome.

Aim: To find out association of elevated ALT with coronary artery disease

Methods: This cross sectional study was carried out on 100 patients presented with clinically suspected CAD. Serum ALT was measured. Patients underwent angiography and images of coronary arteries were obtained and presence of CAD was noted. Relative risk was calculated to measure association between raised ALT and CAD.

Results: The mean age range of patients was 49.16±10.15 years. There were 78 male and 22 female patients. The male to female ratio was 3.54:1. The mean ALT was 41.58±16.18U/L. Coronary angiography findings showed that 29% patients had normal coronaries, 4% had mild CAD, 49% had moderate CAD and 18% had severe CAD. There were 1.8 times high risk of CAD in patients with raised ALT.

Conclusion: It is concluded that although difference in CAD and raised ALT is insignificant but the risk of CAD is 1.8 times high in patients with raised ALT.

Keywords: Coronary Artery Diseases, Serum Alanine Transaminase



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