Aim: To determine whether the pretreatment with thiopental sodium 0,5mg is
better than lidocaine 40mg to prevent the pain associated with propofol
Study Design: Randomized control trial.
Place & Duration: Department of Anesthesiology, Central Park Medical College and Hospital
Lahore from 1st January 2019 to 30th June 2019.
Methods: One hundred cases of ASA I-II aged 18-20 years old for elective surgery
under general anesthesia were included. They were divided in two groups; group
A and group B, each comprised 50 patients. At the time of induction of general
anesthesia, group A was pretreated with injection thiopental sodium 0,5mg /kg
and group B was with injection lidocaine 40mg after applying the tourniquet.
All study drugs were made into 2ml with normal saline. The patient were
observed and asked for pain after every 5-10 sec during the induction of
Results: Patients in group A reported a significantly less pain as compared to
Conclusion: Using the thiopental sodium 0,5mg/kg before induction with propofol
injection is better and safe to prevent the pain caused by propofol injection
is better than lidocaine 40mg in elective surgery.
Keyword: Propofol, Thiopental sodium, Lidocaine