Aim: To examine the prevalence of acquired dysfibrinogenemia
in patients presented with chronic liver disease.
Study Design: Cross-sectional
Place and Duration of Study: Department
of Hematology, Shaikh Zayed Hospital Lahore from 1st September 2019
to 29th February 2020.
hundred and thirty patients of both genders presented with chronic liver
disease having ages 20 to 65 years were enrolled. Patients detailed demographics
including age, sex and causes of chronic liver disease were recorded after
written consent. Blood sample was taken from all the patients to measure
fibrinogen level, prothrombin time, activated partial thromboplastin time,
serum albumin and bilirubin. Severity of chronic liver disease was graded by Child-Pugh
(69.23%) were males while 40 (30.77%) were females with mean age 46.26±15.47
years. Hepatitis C virus was the most common etiology in 98 (75.48%) patients
followed by hepatitis B virus in 24 (18.46%) and hepatitis B virus and hepatitis
C virus both in 8 (6.15%) patients. Acquired dysfibrinogenemia was found in 70
(53.85%) patients. A significant association of increased prevalence of
acquired dysfibrinogenemia with severity of disease was observed according to Child-Pugh
score graded (p<0.05).
Conclusion: The prevalence of acquired dysfibrinogenemia
was quite high in patients with chronic liver disease.
Keywords: Chronic liver disease, Fibrinogen level,
Thrombin time, Thrombosis