Ghazanfar Ali Sirhindi, Yousaf Ali Sirhindi, Aleema Ali Sirhindi, Ameer Abbas Ali
Pakistan Journal of Medical & Health Sciences

Peer Reviewed

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Determine the Prevalence of Acquired Dysfibrinogenemia in Patients Presented with Chronic Liver Disease

Ghazanfar Ali Sirhindi, Yousaf Ali Sirhindi, Aleema Ali Sirhindi, Ameer Abbas Ali




Aim: To examine the prevalence of acquired dysfibrinogenemia in patients presented with chronic liver disease.

Study Design: Cross-sectional

Place and Duration of Study: Department of Hematology, Shaikh Zayed Hospital Lahore from 1st September 2019 to 29th February 2020.

Methods: One hundred and thirty patients of both genders presented with chronic liver disease having ages 20 to 65 years were enrolled. Patients detailed demographics including age, sex and causes of chronic liver disease were recorded after written consent. Blood sample was taken from all the patients to measure fibrinogen level, prothrombin time, activated partial thromboplastin time, serum albumin and bilirubin. Severity of chronic liver disease was graded by Child-Pugh score.

Results: Ninety (69.23%) were males while 40 (30.77%) were females with mean age 46.26±15.47 years. Hepatitis C virus was the most common etiology in 98 (75.48%) patients followed by hepatitis B virus in 24 (18.46%) and hepatitis B virus and hepatitis C virus both in 8 (6.15%) patients. Acquired dysfibrinogenemia was found in 70 (53.85%) patients. A significant association of increased prevalence of acquired dysfibrinogenemia with severity of disease was observed according to Child-Pugh score graded (p<0.05).

Conclusion: The prevalence of acquired dysfibrinogenemia was quite high in patients with chronic liver disease.

Keywords: Chronic liver disease, Fibrinogen level, Thrombin time, Thrombosis

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