: As the most frequent malignancy among women all over the world, breast
cancer accounts for 25% of all cancers and the leading cause of female
cancer-related mortality. It is the most commonly diagnosed malignancy among
the Iraqi population, constituting about one-third of the registered female
cancers and the leading cause of death from malignant neoplasm among women. Breast
cancer women are also diagnosed with vitamin D3 deficiency, and low levels of
serum vitamin D are reported to be associated with recurrence, invasiveness,
and mortality. Moreover, women with higher levels of serum vitamin D3 are twice
more likely to survive than those with low levels.
Aim: To evaluatie the association of vitamin D3 receptor with
susceptibility to breast cancer in Iraqi women.
Method: This study
was a retrospective-prospective study, carried out at Nanakali
hematology/oncology hospital of Erbil on a sample of 74 cases who were randomly
selected from among women who were diagnosed with breast cancer (stage II and
stage III) from July to December 2016. The collected data were analyzed using Cho-square
test and T-test through Graphpad Prism program version 6.
Results: Based on
the results of the present study, 45% of patients were premenopausal, whose risk
of ER+PR+ tumors was 20% lower. There were no significant differences between
premenopausal, menopausal and postmenopausal breast cancer patients with
different BMI groups regarding molecular subtypes. Moreover, there was a significant
association between obesity and hormonal receptor subtype ER+/PR+.
Conclusion: Most of
the Iraqi women with breast cancer are either obese or overweight at the time
of diagnosis. There is a weak inverse association between vitamin D levels and
breast cancer risk. Serum calcium and estrogen levels are positively associated
with breast cancer risk.
Keywords: Perimenopause, breast cancer, androgen
receptor, vitamin D receptor, diagnosis