Muthanna I. Al-ezzi, Raghad A. Mohsin, Huda Jaber Waheed


1002



ABSTRACT

 

Background: Acute myocardial infarction (AMI) is an atherosclerotic disorder of myocardial necrosis caused by constriction of blood supply to the heart, leading to myocardial dysfunction and death of the heart cells. Vitronectin (VN) is a regulatory plasma glycoprotein, which adjusts the adhesion processes of platelets, accumulation and coagulation.

Aim: To investigate the correlation between serum VN level and acute myocardial infarction (MI) in the presence and absence of diabetes.

Method: This study includes 30 patients with acute myocardial infarction which were selected from Iraqi hospitalized patients in the intensive care unit. Those patients were subdivided into two groups: group 1 involved 6 (53.3) % patients with diabetic complications; group 2 involved 14 (46.6) % patients as a non-diabetic group and 30 as control group. After an overnight fasting, 10ml of venous blood from all patients and healthy subjects was drawn to investigate the biomarkers (vitronectin, lipid profile, blood urea) in addition to having the body mass index (BMI) of all the groups.

ResultsThe results displayed significant difference in the level of vitronectin, blood urea, TC, LDL-C and HDL-C between patients with AMI (diabetic and non-diabetic) compared to control group, while there was non-significant difference in the level of TG and VLDL-C in diabetic patients with AMI compared to control group. At the same time, there was a positive correlation between vitronectin, BMI and TC.

Conclusion: The results of the present study were based on a small population of patients suffering from acute myocardial infarction. Some of them were complicated with diabetes. All of them presented a high level of vitronectin which may have a significant role in the induction of AMI, thus represent as a pathogenic factor for atherosclerosis. Hence, we recommend the use of this biomarker as a diagnostic test for AMI, however, more studies are needed to confirm these findings.

Key words: acute myocardial infarction, vitronectin, diabetes.



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