Relationship Between Vitamin D Deficiency and Proteinuria in Patients with Ckd

Abstract

Background: People with chronic kidney disease are at a higher risk of kidney failure and developing vitamin D deficiencies.

Objective: The aim of this study was to find out the association of vitamin D deficiency and proteinuria in patients with CKD

Materials and Method: The current study was conducted at the department of Medicine Khalifa Gul Nawaz teaching Hospital/Bannu Medical college, Bannu from January 2023 to April 2023 following approval from the ethical committee of the hospital. A total of 80 individuals were enrolled in our study.Written consent were taken from each participant. Clinical and demographic features including weight, sex, age height, marital status, income status, blood pressure were recorded. Laboratory factors such as 25 OH vitamin D3, electrolytes, urea, creatinine, hemogram, and parathormone, of each patent were assessed on specified forms. Data was analyzed using SPSS version 22 and the p value less than 0.005 was considered significant.

Results: In this study a total of 180 individuals were enrolled with chronic kidney disease, out of which 51(63.5%) were female and 29 (36.3%) were male. The mean age of the study participants’ were 59.1±10.8 years.  The deficiency of vitamin D was found in 15 (18.75%) cases . Participants with deficiency of vitamin D had 628.8 mg/g median UACR, those with sufficient vitamin D levels had 95 mg/g and with insufficient had 330.8 mg/g. So the prevalence of albuminuria increased with vitamin D deficiency

Conclusion: Our study concluded that individual with CKD had significantly high vitamin D deficiency and proteinuria was strongly associated with vitamin D deficiency. The prevalence of proteinuria increased with vitamin D deficiency.

Keywords: Relationship; Vitamin D deficiency; Proteinuria; CKD