Naveed Shuja
Pakistan Journal of Medical & Health Sciences




Peer Reviewed

Previous Published Issues



455




Introduction

Throughout history, many different cultures have recognized the potential use of garlic for prevention and treatment of different diseases1. Recent studies support the effects of garlic and its extracts in a wide range of applications2,3. These studies raised the possibility of revival of garlic therapeutic values in different diseases. Different compounds in garlic are thought to reduce the risk of bacterial infections11. The use of garlic in treating infections is a long-standing tradition in many cultures1,6. However, it was not until recent years the exact reason why garlic has so much antibacterial, antifungal and antiviral properties were studied4. Allicin is the most prominent compound found in garlic and has excellent antimicrobial functions. It is the most active compound in garlic which gives it these properties5. Allicin is highly effective against MRS (Multidrug Resistance Strains) bacterias which makes it highly valuable for the medical community. Another component found in garlic called as Ajoene is also capable of treating fungal infections such as athlete’s foot which many people suffer from worldwide7. Garlic extract can also be used for the treatment of influenza and herpes viruses and can deliver positive results.This compound can easily eradicate bacteria by resisting the production or blocking the enzymes that are directly responsible for several vital functions of the bacteria such as energy production and cell structure formation. Without the necessary energy, the bacterias will die off in no time7,2. Allicin can also actively inhibit the formation of biofilms which is one of the major defence mechanisms employed by bacterias and fungus. The formation of biofilms makes the treatment of these infections very difficult and garlic can be used to prevent the formation of biofilms8,5.



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