Tanveer Ahmed Ansari, Salma Kadir, Barkat Ali Dahar, Muhammad Atif Baig, M Joher Amin, Safdar Ali Shaikh
Pakistan Journal of Medical & Health Sciences




Peer Reviewed

Previous Published Issues


The Effectiveness of Carvedilol Versus Propranol in Preventing Recurrence of Bleeding in Cirrhotic pt

Tanveer Ahmed Ansari, Salma Kadir, Barkat Ali Dahar, Muhammad Atif Baig, M Joher Amin, Safdar Ali Shaikh



596




ABSTRACT

Aim: To determine the effectiveness of carvedilol versus propranol to prevent recurrence of bleeding in cirrhotic patients. Study design: Controlled trial study Place and duration of study: Department of Medicine, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat from 1st April 2020 to 30th November 2020. Methodology: One hundred and eighty patients of ages between 20-60 years were presented in this study. Patients detailed demographics age, sex, body mass index and Child-Turcotte-Pugh (CTP) class were recorded. Patients were equally (n=90) divided into two groups. Group I had 90 patients and received carvedilol while group II had 90 patients and received propranol for 8 months. Reoccurrence of bleeding in cirrhotic patients among both groups were observed at 4th and 8th months in which pulse rate, arterial pressure and portal vein flow were recorded. Results: There were 120 (66.7%) male patients (60 in Group I and 60 in Group II) and 60 (33.3%) were females (30 in Group I and 30 in Group II). Mean age of the patients in group I was 42.18±9.77 years with mean BMI 27.15±7.18 kg/m2 and in group II mean age was 42.84±4.96 years with mean BMI 27.61±2.81 kg/m2. Child-Turcotte-Pugh class did not show any significantly difference among both groups. 24 (26.7%) reoccurrence of blooding observed in group I and 45 (50%) reoccurrence of bleeding was in group II. After 4 and 8 months, in carvedilol group I pulse rate, mean arterial pressure and portal vein flow was found lower as compared to propanol group II with p value < 0.05. Conclusion: Carvedilol drug was more effective and safe to prevent reoccurrence of bleeding in cirrhotic patients as compared to propanol drug. Keywords: Carvedilol, Propanol, Portal vein flow, Mean arterial pressure



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