Tazeen Kohari, Aftab Ahmad, Qanbar Abbas Naqvi, Aaqiba Rasheed, Naureen Waseem
Pakistan Journal of Medical & Health Sciences




Peer Reviewed

Previous Published Issues


Efficient Effect of Chronic Methylcobalamin Administration on Cerebellar Purkinje Cell Diameter

Tazeen Kohari, Aftab Ahmad, Qanbar Abbas Naqvi, Aaqiba Rasheed, Naureen Waseem



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ABSTRACT

Background: Cerebellar cortex contains five varieties of neurons granule cells, basket, Purkinje, granule, Golgi and three layers molecular, Purkinje, granule cell layer. Purkinje cells are the only sole output of cerebellar cortex. Neurons were distorted by the use of Lithium Carbonate which is popularly used in psychiatric disorder.

Aim: To provide a morphometric data of restoration of Purkinje cell diameter after 6 weeks use of injectable methylcobalamin.

Method: Fifteen animals were given Lithium Carbonate and methylcobalamin for a period of 6 weeks.

Results: Results obtained of the restored Purkinje cell diameter supported the need of educating the consultants in prescribing methylcobalamin in psychiatric disorders.

Conclusion: The strength of this study is a documented proof of the restoration of Purkinje cell diameter after methylcobalamin administration which will help in prescribing methylcobalamin as the neuroprotector in future.

Keywords: Purkinje Cells, Restoration, neuroprotector



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