Aim: To determine
the diagnostic accuracy of diffusion weighted magnetic resonance imaging for
differentiation of Brain abscesses from brain lesions taking surgical findings
as gold standard.
Methods: This cross
sectional study was done at department of Radiology, Lahore General Hospital, Lahore.
The study was completed in Six
Months (October 1, 2014 till March 31, 2105). After taking informed consent,
demographic information (name, age, gender and contact) was obtained. Then
patients underwent through Diffusion weighted imaging (DWI).
Diffusion-sensitizing gradients were applied with a diffusion sensitivity of b
= 0, 500 and 1000s/mm2. Apparent diffusion coefficient (ADC) values
were also calculated on computer software. ADC values were taken from the
center and wall of the lesion as well as from the surrounding oedema. DWI were
analyzed on the basis of signal intensity on diffusion images and corresponding
ADC maps. Then patients were underwent biopsy for histopathology. All biopsy
samples were sent to the histopathology laboratory of hospital and results were
compared with results of DWI.
mean age of the patients was 43.74±14.64 years with minimum and maximum ages of
20 & 70 years respectively. Out
of 145(65.91%) patients were male and 75(34.09%) patients were females. The
male to female ratio was 1.933:1. The sensitivity of DWI in our study was
91.67%, specificity was 93.18%, positive predictive value was 95.28%, negative
predictive value was 88.17% and the diagnostic accuracy was 92.27% taking
histopathology as gold standard.
Conclusion: Diffusion weighted imaging is an effective method with high sensitivity
and specificity which can help in differentiation of Brain abscesses from brain
weighted imaging, DWI, Histopathology, Brain Lesions, Restriction, Abscess