Diabetes Mellitus Type 2 Associated Alterations in the Regulation of Blood Sugar, Kidney Function and Oxidative Stress


  • Mudassar Ali
  • Faheem Mahmood
  • Sahar Mudassar
  • Zia Ul Mustafa
  • Muhammad Aleem Uddin
  • Mufassar Nishat




Glycemic control, fasting blood glucose, urea, creatinine, total antioxidant capacity, reactive oxygen species.


Background: Diabetes mellitus (T2DM) is a multifactorial disease that produces high blood sugar levels.

Duration of study: February 2019 to April 2021

Place of study: Arif Memorial Hospital , Galwera village, Kasur road Lahore

Method & Result: 50 Pakistani T2DM individuals were investigated. Insulin, insulin resistance (IR), and insulin sensitivity were the glycemic control measures (IS). Renal function tests looked at urea and creatinine. TAC and ROS were oxidative stress indicators (ROS). T2DM patients exhibited greater fasting blood glucose, HbA1c, insulin, and IR than non-T2DM controls. Pseudo-insulin sensitivity reduced in patients (p˂.01). Urea and creatinine levels climbed somewhat in T2DM patients. TAC increased in patients over controls (P˂.05). Less than 2% of T2DM patients had elevated ROS (P˂.02). TAC and fasting blood glucose exhibit a positive (P˂.02) relationship. Fasting blood glucose and IS have a substantial negative relationship (P0.01). HbA1C correlates with IR, creatinine, and TAC but not with ROS (P˂.01). HbA1C and IS had a strong (P0.01) negative relationship. Diabetes mellitus is associated with insulin resistance (IR). Significant IS, creatinine, and ROS interactions (P˂.01). IS and urea are antithetical (P˂.05). Urea and creatinine have a strong (P˂.01) connection. TAC is anti-ROS (P˂.05).

Conclusion: Glycemic instability in diabetic’s More than persistent hyperglycemia, blood glucose fluctuations may cause oxidative damage. The strong positive connection between fasting blood glucose and the other investigated measures shows that hyperglycemia is an independent risk factor for T2DM development.