Therapeutic Effect of Antioxidant Extract of Ocimum Gratissimum on Liver Toxicity Model in Rats

Authors

  • Muhammad Shahid Javed, Sohail Iqbal, Nida Qasim Hayat, Attya Zaheer, Fatima Qaiser, Faiza Irshad, Amal Shaukat

DOI:

https://doi.org/10.53350/pjmhs22163643

Keywords:

Hepatobiochemical; Lead; Liver; Ocimum gratissimum; Wistar rats; Parameters

Abstract

Background:Lead harms haematological, biochemical, and hepatic parameters, hence studies have concentrated on antioxidants with therapeutic potentials.

Objective: Induced hepatotoxicity and hemato-biochemical parameters in adult Wistar rats with Ocimum Gratissimum extract.

Methodology: 42 adult Wistar rats were divided into seven groups of five. Group A was the control, Group B had 120 mg/kg lead, and Group C got 300 mg/kg OG. D and E had 120 mg/kg lead before 300 mg/kg and 600 mg/kg OG. Group F had 300 mg OG extract, then 120 mg lead, whereas Group G got 120 mg lead and 1000 mg ascorbic acid. The animals were then slaughtered and blood and liver tissues were taken for biochemical and histological investigation.

Results: The outcome revealed a rise in Control but a drop in B. ALT, AST, GGT, and ALP levels were higher in Group B than in Control and other treatment groups (p≤ 0.05). As in Groups D, E, F, and G, histological investigation of liver tissues revealed degenerative alterations with localised necrosis and aggregated inflammatory cells in B.

Conclusion: The extract of OG has the potential to be employed as a medicinal agent in the treatment of lead poisoning.

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How to Cite

Muhammad Shahid Javed, Sohail Iqbal, Nida Qasim Hayat, Attya Zaheer, Fatima Qaiser, Faiza Irshad, Amal Shaukat. (2022). Therapeutic Effect of Antioxidant Extract of Ocimum Gratissimum on Liver Toxicity Model in Rats. Pakistan Journal of Medical & Health Sciences, 16(03), 643. https://doi.org/10.53350/pjmhs22163643