Assessment of the Frequency of Different Patterns of Clinical Presentation of Children Presenting with Congenital Adrenal Hyperplasia

Authors

  • Muhammad Hamza, Feezan Raza, Moqeet Hayat, Attaullah Bangulzai, Syed Aqeel Akbar Shah Gillani, Murtaza Jaffar

DOI:

https://doi.org/10.53350/pjmhs22163593

Keywords:

Patterns, salt depletion, genital virilization, congenital adrenal hyperplasia, infants, consanguineous marriage.

Abstract

Background: Congenital suprarenal hyperplasia is an autosomal recessive condition that is characterized by defects in some of the 5-enzymes required for cortisol synthesis. Literature indicates a high incidence of salt depletion and genital virilization in children with congenitally adrenal hyperplasia. The purpose of this study was to examine the prevalence of clinical patterns in children with congenital adrenal hyperplasia.

Material and methods

Study design: Cross sectional study

Setting: Department of Pediatric, Fatima Memorial Hospital, Lahore.

Duration: 6 months i.e. 19-12-2019 to 18-06-2020

Data collection: 92 infants who met the inclusion criteria were included in the study. Blood sample was obtained, if serum sodium was <135mEq/L, salt depletion was labeled. Then, genital examination for assessment of genital virilization was done. All data was entered in specially designed Performa and analyzed in SPSS.

Results: The mean age of patients was 6.52±3.56 months. There were 49 (53.26%) male while 43 (46.74%) female infants. The mean weight of patients was 5.59±1.44 kg. There were 21 (22.83%) cases of consanguineous marriage while 71 (77.17%) were others. 63 (68.48%) had salt depletion while 29 (31.52%) did not had salt depletion. 39 (42.39%) patients had genital virilization while 53 (57.61%) did not have genital virilization.

Conclusion: The frequency of patterns (salt depletion and genital virilization) of Congenital adrenal hyperplasia are high in local population.

Downloads

How to Cite

Muhammad Hamza, Feezan Raza, Moqeet Hayat, Attaullah Bangulzai, Syed Aqeel Akbar Shah Gillani, Murtaza Jaffar. (2022). Assessment of the Frequency of Different Patterns of Clinical Presentation of Children Presenting with Congenital Adrenal Hyperplasia. Pakistan Journal of Medical & Health Sciences, 16(03), 593. https://doi.org/10.53350/pjmhs22163593

Issue

Vol. 16 No. 03 (2022): Pakistan Journal of Medical & Health Sciences

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.