Comparison of Outcomes of Dexmedetomidine vs Midazolam for Sedation in Mechanically Ventilated Neurosurgical Patients

Abstract

Aim: To compare the outcomes of dexmedetomidine versus midazolam for sedation in mechanically ventilated neurosurgical patients at Tertiary Care Hospital, Karachi.

Study design: Randomized control trial.

Place and duration of study: Department of Anesthesia, JPMC, Karachi from 20^th November 2020 to 20^th May 2021.

Methodology: One hundred patients who met the diagnostic criteria were enrolled. Brief history was taken and demographic information was noted.

Results: Mean ages and duration of mechanical ventilations in dexmedetomidine group was 49.78±10.54 years and 93.54±10.53 hours while in midazolam group was 50.41±12.39 years and 117.50±15.51 hours. Mean extubation time in the dexmedetomidine and midazolam group was 35.27±0.57 minutes and 48.84±0.53 minutes and statistically the difference was significant (P=0.01). Whereas, mean Ramsay sedation score in the dexmedetomidine and midazolam group was 3.03±0.04 and 3.92±0.06. P-value was 0.01.

Conclusion: Dexemedetomidine prove to be drug of good choice for sedation during neurosurgical mechanism as compared to midazolam. It also showed good extubation time and hemodynamic stability.

Keywords: Dexmedetomidine, Midazolam, Sedation, Mechanically ventilated, Hemodynamic changes, Neuro-protection