Effects of Mirabegron vs Tamsulosin in Reducing Lower Urinary Tract Symptoms in patients with Indwelling Double J Stents

Authors

  • Hafiz Muhammad Yousaf Khan, Ahmed Raza, Jamshed Rahim, Muhammad Rameez, Syed Umer Farooq, Ubaid-ur-Rehman

DOI:

https://doi.org/10.53350/pjmhs2023171103

Abstract

Aim: To compare the mean IPSS score after treatment with tamsulosin versus mirabegron in patients with double J stent related lower urinary tract symptoms.

Study design: Randomized controlled trial.

Place and duration of study: Department of Urology Shaikh Zayed Hospital, Lahore from 2nd May 2019 to 1st November 2019.

Methodology: One hundred patients of both genders aged between 18-60 years having DJ stent related symptoms (IPSS score ≥7) were enrolled. Patients were randomized into 2 groups based on treatment. Patients in Group A were given mirabegron while the one in Group B were treated with tamsulosin. Outcome variable was mean IPSS score 3 weeks after treatment which was noted and compared between the groups.

Results: The mean age was 38.6±10.9 years. There were 59 (59.0%) male and 41 (41.0%) female patients with a male to female ratio of 1.4:1. The IPSS score at baseline ranged from 14 to 23 with a mean of 18.18±2.77. The follow-up IPSS score was significantly lower in patients treated by mirabegron as compared to tamsulosin (6.28±0.86 vs. 9.60±0.86; p-value<0.001). Similar significant difference was noted between the groups across various subgroups based on patient’s age, gender and baseline IPSS score.

Conclusion: Mirabegron was superior to conventional practice of tamsulosin in the treatment of DJ stent related symptoms in terms of significantly lower mean IPSS score after 3 weeks of treatment.

Keywords: DJ stent, Lower urinary tract symptoms, Mirabegron, Tamsulosin

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How to Cite

Hafiz Muhammad Yousaf Khan, Ahmed Raza, Jamshed Rahim, Muhammad Rameez, Syed Umer Farooq, Ubaid-ur-Rehman. (2023). Effects of Mirabegron vs Tamsulosin in Reducing Lower Urinary Tract Symptoms in patients with Indwelling Double J Stents. Pakistan Journal of Medical & Health Sciences, 17(01), 103. https://doi.org/10.53350/pjmhs2023171103